Chemical name: [1(1S,2R),5(S)]-2,3,5-trideoxy-N-(2,3-dihydro-2-
Hydroxy-1H-inden-1-yl)-5-[2-[[(1,1-dimethylethyl)amino]-4-(3-pyridinylmethyl)-1-piperazinyl]-2-(phenylmethyl)-D- erythro- pentonamide sulfate (1:1) salt
Molecular Formula: C36H47N5O4 · H2SO4
Molecular structural:
Molecular weight: 711.88
CAS No.: 157810-81-6
Mechanism of action: HIV-1 protease is an enzyme required for the proteolytic cleavage of the viral polyprotein precursors into the individual functional proteins found in infectious HIV-1. Indinavir binds to the protease active site and inhibits the activity of the enzyme.This inhibition prevents cleavage of the viral polyproteins resulting in formation of immature non-infectious viral particles.
Indication and usage: Indinavir in combination with antiretroviral agents is indicated for the treatment of HIV infection. This indication is based on two clinical trials of approximately 1 year duration that demonstrated: 1) a reduction in the risk of AIDS-defining illnesses or death; 2) a prolonged suppression of HIV RNA.
Packaging and storage: 25kg fibreboard drum lined with 2-ply PE bags, store in tightly-closed container at room temperature. Protect from moisture. |
